Photodynamic Therapy (PDT) for Skin Cancer in London: Consultant-Led, Targeted Light Treatment at Skinhorizon Clinic

Photodynamic Therapy (PDT) is one of the most advanced non-surgical treatments for skin cancer and precancerous lesions in London. At Skinhorizon Clinic Maida Vale, PDT is performed under direct supervision of Consultant Dermatologist Dr Mohammad Ghazavi, ensuring the highest standards of safety, precision, and clinical care.

This targeted light-based therapy selectively destroys abnormal cells while preserving surrounding healthy tissue — making it an excellent option for conditions such as actinic keratosis, Bowen’s disease, and early superficial basal cell carcinoma.

What Is Photodynamic Therapy (PDT)?

PDT is a medical treatment that combines a photosensitising cream with a specific wavelength of light energy to destroy abnormal or cancerous skin cells. The photosensitiser accumulates in damaged cells and, when activated by light, triggers a reaction that eliminates them without harming surrounding healthy tissue.

When Is PDT Used?

At Skinhorizon Clinic, PDT is primarily used for:

• Actinic Keratosis (AK): Sun-induced precancerous spots, especially on the face, scalp and hands.
• Bowen’s Disease: Early-stage squamous cell carcinoma in situ.
• Superficial Basal Cell Carcinoma (BCC): Shallow forms of skin cancer where surgery may leave scarring.
• Field Cancerisation: Areas of widespread sun damage at risk of developing multiple precancerous lesions.

How Does Photodynamic Therapy Work?

1. Preparation: The lesion is gently cleansed and prepared to remove crusts or scales.
2. Application: A photosensitising agent (usually aminolevulinic acid or methyl aminolevulinate) is applied to the affected area.
3. Incubation: The cream is left to absorb into the skin for 1.5–3 hours.
4. Activation: The area is exposed to a specific wavelength of red light using a calibrated medical device such as the GME PDT system.
5. Cell Destruction: The light activates the photosensitiser, destroying abnormal cells while sparing healthy tissue.

Advantages of PDT Over Surgery

• Non-invasive and scar-free
• Targets abnormal cells selectively
• Suitable for facial or cosmetically sensitive areas
• Minimal risk of infection or bleeding
• Excellent cosmetic outcome
• Can treat large or multiple lesions simultaneously

What to Expect During and After PDT

Most patients experience a mild burning or tingling sensation during light exposure, which lasts 8–15 minutes. This is well tolerated and often managed with cooling fans or the TargetCool® CO₂ cooling device. After treatment, the area may appear red or crusted for a few days, similar to mild sunburn.

Healing usually occurs within 7–10 days for facial lesions and 2–3 weeks for limbs. Once healed, the treated skin looks smoother, healthier, and less sun-damaged.

Is PDT Effective for Skin Cancer?

Yes. Clinical studies have shown high cure rates for superficial BCC and Bowen’s disease, often comparable to surgery but with superior cosmetic outcomes. It is also an ideal choice for patients who cannot undergo surgery or prefer a non-invasive alternative.

PDT for Actinic Keratosis and Sun-Damaged Skin

Actinic keratoses are precancerous lesions caused by cumulative sun exposure. PDT not only removes visible lesions but also treats the surrounding “field” of damaged skin, reducing the likelihood of recurrence. The result is clearer, smoother skin with improved texture and tone.

Who Performs PDT at Skinhorizon Clinic?

All PDT procedures are carried out or supervised by Dr Mohammad Ghazavi, Consultant Dermatologist and Fellow of the Royal College of Physicians. His expertise ensures precise lesion targeting, accurate diagnosis, and adherence to the latest NICE guidelines for skin cancer management.

Other Non-Surgical Skin Cancer Treatments We Offer

• Cryotherapy for superficial lesions
• Diagnostic Biopsy & Histopathology
• CO₂ Laser for post-cancer scar refinement
• LED Phototherapy for post-procedural healing

Why Choose Skinhorizon Clinic?

• Consultant-led dermatology and laser oncology care
• On-site diagnostic imaging and biopsy services
• Advanced GME PDT medical system
• CQC-registered facility in Maida Vale, West London
• Personalised treatment plans based on skin type and lesion depth

Frequently Asked Questions